001403 - Impact on IgE of therapy using auto serum injections for cold allergy and insect allergy

Changes in the level of total and allergen-specific Ig E in patients  allergy may occur consequent to use of auto serotherapy. This study evaluates these parameters before and after treatment with auto serum in patients with insect allergy and patients with documented cold induced allergy.

0 patients who were assessed were divided into 3 groups: Group  1 - patients with cold allergy (N = 28);  Group 2 - patients with insect allergy (N =22); and Group 3 - a control group of healthy volunteers (N = 30). In all patients, the level of total and specific IgE was determined before and after auto serotherapy. In patients of Group 1, cold allergy was diagnosed using a cold exposure test. Patients of Group 2 had sensitization confirmed by positive specific Ig E level to insect allergens (Euroimmune, Germany). Patients were provided  autoserotherapy from October to December 2021-2024. The course consisted of 10 subcutaneous injections, which patients received for 14 days at the Minsk City Transfusion Center. Then after a  2-week break, this course was  repeated using 10 subcutaneous injections for 14 days.

A statistically significant decrease in the level of total serum IgE was found in the Group 2  patients with insect allergy (from 312[286;316] ME/ml to 168[148;184] ME/ml), while there was no decrease in the sensitization class. Patients in Group 1 with cold allergy showed no decrease in the level of total serum IgE (210[187;316] ME/ml before treatment versus 187[172;206] ME/ml after treatment). More than 80% (CI 95%;77-92%) of patients noted reduction or a complete absence of allergy symptoms in both study groups (p<0.05).

A significant decrease in the level of total serum IgE was detected in the patients with insect allergy during auto serum therapy, while there was no decrease in the sensitization class. In patients with cold allergy, a decrease in the level of total serum IgE during auto serum therapy was not detected, suggesting different mechanisms for cold allergy versus insect allergy.