D2.375 - Concomitant allergic and ENT pathology in children with chronic inflammatory diseases

Objective: to determine the incidence of allergic pathology and ENT diseases in children with chronic inflammatory diseases using inflammatory bowel disease (IBD) and psoriasis as an example.

the prospective study included 40 children (57.5% - boys) aged 6 to 17 y 11 mo (mean 12.5±3.6) with chronic inflammatory diseases - 20 children with IBD and 20 children with psoriasis; the control group consisted of 20 healthy children. The examination included an assessment of the ENT status (with ENT endoscopy), laboratory examination (determination of serum proinflammatory cytokines levels), consultations with a pediatrician, allergist, dermatologist, gastroenterologist.

allergic pathology - allergic rhinitis - was detected in 20% children in the psoriasis group. In patients with psoriasis and allergic rhinitis a statistically significant increase in the levels of IL-18 (mean 284.66 in the study group and 164.98 in the control group, p = 0.0028), as well as a tendency to increase IL-23 were detected.

The leading ENT pathology in both observation groups was the pathology of the palatine tonsils - chronic tonsillitis: 40% of patients with psoriasis and 30% of children with IBD. In children with psoriasis and chronic tonsillitis a significant increase in IL-18 levels (mean 228.70 in the study group and 164.98 in the control group, p = 0.031), as well as a tendency to increase IL-23, were found.

In patients with IBD and chronic tonsillitis, a significant increase in MDC/CCL22 levels (mean 1.182 in the IBD group and 0.827 in the control group, p = 0.0331) and IL-23 (mean 2.670 in IBD patients and 0.955 in the control group, p = 0.001) were found.

concomitant allergic and ENT pathology can affect the immunophenotype of patients with chronic inflammatory diseases. A personalized approach based on the phenotypic characteristics of the patient can help prevent the progression of the underlying disease and the development of exacerbations, considering concomitant inflammatory processes of the upper respiratory tract.