D3.313 - Chronic Spontaneous Urticaria and its relationship with Allergies to Aerogenic Fungi: dermographism, skin hyperreactivity, and chemical patterns of inflammation

Chronic Spontaneous Urticaria (CSU) is a dermatological condition characterized by the recurrent appearance of raised hives or hives on the skin, angioedema or both, which have a varied origin, with a great impact on thequality of life of patients. In recent times, there has been great interest in understanding the possible relationship between CSUs and allergies to aerogenous fungi.The objective of the study was to determine the characteristics of CSU (Chronic Spontaneous Urticaria) and its relationship with aerogenic fungi in children from 4 to 11 years old.

A non-experimental, descriptive-correlational, and cross-sectional quantitative study was carried out. The sample was made up of 170 children who attended the CIPeA Laboratory (Center for Pediatric Immunology Asthma and Allergy) of the Province of Tucumán during the year 2021-2022, and who attended due to the appearance of urticaria.

Of the sample, 51% (86) were male, and 49% (84) were female; 45% (78) were between 4 and 6 years old; In the family history of atopy, the most frequent paternal history was Sinusitis, and the maternal history was Rhinitis; 98% (165) of participating children were positive for UCE hyperreactivity; 72% (123) had moderate to severe levels for UAS7 in the wheal score, with similar percentages for the pruritus score. The biopsy was positive in 94%. No statistically significant association was found in wheal and pruritus, according to Candida - Penicillium - Aspergillus - Clodosporium (p˃0.005).

It is necessary to continue working on the characterization of these populations, in order to find increasingly specific therapies for Chronic Spontaneous Urticaria in childhood ages.