D3.382 - Evaluation of Serum Arginase-1 Levels in Chronic Urticaria
Background
Chronic urticaria (CU) is a skin condition involving hives and itching lasting over six weeks, with potential autoimmune involvement. The study aimed to evaluate serum arginase-1 (ARG1) and interleukin-6 (IL-6) levels in CU patients compared to healthy controls (HC) and to investigate their relationship with disease activity.
Method
A case-control study was conducted, involving 50 CU patients and 38 age and sex-matched healthy individuals. Serum ARG1 and IL-6 levels were measured using ELISA. Disease activity was assessed with Urticaria Activity Score (UAS7) and Urticaria Control Test (UCT). Statistical analyses were performed using SPSS.
Results
The CU group showed significantly higher serum ARG1 levels compared to the HC group, but no significant difference in IL-6 levels. A weak positive correlation between serum ARG1 and IL-6 was observed. Additionally, CU patients had significantly higher C-reactive protein (CRP) levels than controls.
Conclusion
Elevated ARG1 levels in CU suggest a potential role in its pathogenesis, likely linked to Th2-mediated inflammation. Although no significant differences in IL-6 levels werefound, the correlation between ARG1 and IL-6 supports their involvement in CU's inflammatory processes. Further research is needed to explore ARG1 as a potential therapeutic target.
