D2.354 - Evaluation of Subjective Sleep Quality and Psychological Status in Adult Patients with Inborn Errors of Immunity

Inborn errors of immunity are chronic conditions associated with an increased risk of malignancies, recurrent infections, and psychological disorders. Patients with chronic health conditions frequently report poor sleep quality. A limited number of studies on sleep quality in IEI have been published. We aimed to evaluate sleep quality and psychological status in patients with inborn errors of immunity (IEI).

Adult patients (≥18 years) diagnosed with IEI and without sleep disorders were included in this study. Demographic data, comorbidities, laboratory findings were recorded. The Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Insomnia Severity Index (ISI) were administered to patients with IEI. The cardinal symptoms of sleep apnea, including snoring, witnessed apnea, and excessive daytime sleepiness, were assessed.

Among 80 patients with IEI, 41 (51.2%) were female. The mean age and mean diagnostic delay of IEI were 42.9±15 years and 11±13 years, respectively. The mean PSQI was 6.29±3.7, indicating poor sleep quality. The mean sleep duration and the mean sleep latency were 6.59±1.6 hours and 36±34 minutes, respectively. Poor sleep quality was observed in 56.3% of the patients (n=45). According to BDI, the mean score was 13.5±9.4, indicating mild depression. The mean BAI score was 11.4±10, consistent with mild anxiety. ISI revealed no clinically significant insomnia with a mean score of 7.89±6. Snoring was present in 38.8% of patients, witnessed apnea in 17.5%, and excessive daytime sleepiness in 41.3%. Symptoms of insomnia, subjective sleep quality, anxiety and depression parameters, and excessive daytime sleepiness were not associated with age, body mass index, or number of hospitalizations (Table1).

As our study demonstrated that poor sleep quality is common among patients with IEI, routine assessment of sleep quality should be included in clinical practice. Further investigation should be performed in this group, and appropriate precautions should be taken.