001163 - Biomarker study to determine the therapeutic efficacy of SCIT in Korean allergic rhinitis children sensitized with house dust mite

The main cause of allergic rhinitis in Korean children is Dermatophagoides farinae and Dermatophagoides pteronyssinus. This study was conducted to examine the biomarkers that appears when performing SCIT with D.farinae and D.pteronyssinus.

We performed a retrospective chart review of pediatric patients aged 5 years or older who started SCIT treatment for D.farinae and D.pteronyssinus allergic rhinitis at the Department of Pediatrics, Inha University Hospital from March 2021 to June 2024. Total nasal symptom score(TNSS) was measured, and IgE, eosinophil, Dp/Df specific IgE antibody , and Dp/Df specific IgG4 in peripheral blood were measured and analyzed statistically. Research approval was obtained from Inha University Hospital IRB.

Eighty-one patients started SCIT treatment for house dust mites. The test results of 66 patients were analyzed after excluding those who dropped out, moved, or did not have blood tests. There were 42 boys and 24 girls, and the age was 8.3 ± 2.9 years. TNSS, IgE, and IgG4 were measured 12.8 ± 1.7 months after starting HDM SCIT. TNSS measured before and after starting SCIT were 10.0 ± 1.1 and 3.0 ± 1.0, IgE was 1082.7 ± 1144.2 and 1176.0 ± 1210.0, D.pteronyssinus was 47.6 ± 31.0 and 37.9 ± 26.8, D.farinae was 82.4 ± 23.0 and 62.6 ± 29.5, IgG4 Dp was 0.9 ± 0.6 and 6.3 ± 3.6, IgG4 Df was 1.9 ± 1.2 and 11.2 ± 6.3.

After 12.8 months of HDM SCIT treatment, rhinitis symptoms significantly improved and IgG4 Dp/Df levels significantly increased. IgG4 is the biomarker highly correlated with effectiveness of SCIT. We are conducting a follow-up examination 30~36 months after SCIT treatment and will announce the results at a later date.