D3.72 - Effect of Helicobacter pylori Eradication on Disease Activity in Chronic Urticaria: Follow-Up Results

Chronic urticaria (CU) is a condition marked by recurrent hives, which may be influenced by various factors, including the presence of Helicobacter pylori (H. pylori) infection. This study investigates the impact of H. pylori eradication on disease activity among patients diagnosed with CU.

A prospective study was conducted on 200 patients (120 males, 80 females) with confirmed chronic urticaria and H. pylori infection. The gender distribution was 60% male and 40% female. All subjects received standard triple-therapy eradication regimens. Patients were assessed for urticaria exacerbations at three and six months post-treatment. The primary endpoints were complete remission (zero exacerbations) and the persistence of symptoms. We checked data from the 6-month follow-up (the final result) to see if the difference between males and females is statistically significant. 

At the three-month follow-up, 128 patients (64.0% of the total cohort) reported complete remission with zero exacerbations. Gender-specific analysis showed that 60.0% of males (72/120) and 70.0% of females (56/80) achieved remission at this stage. By the six-month follow-up, outcomes significantly improved. A total of 188 patients (94.0%) were free of urticaria symptoms. Only 12 patients (6.0% of the total cohort) continued to suffer from active urticaria rash. Breakdown of the persistent cases by gender showed 5 males (4.2% of the male subgroup) and 7 females (8.8% of the female subgroup) remained symptomatic. Statistical analysis using the Chi-Square test revealed no significant difference in treatment outcomes between genders at the six-month follow-up (χ2=1.78, p=0.18). The eradication of Helicobacter pylori demonstrates a substantial positive effect on disease activity in chronic urticaria, with a total remission rate of 94% achieved within six months. While both genders responded well to treatment, the data indicate a slightly higher initial remission rate among females at three months (70% vs 60%), though males maintained a marginally lower rate of persistent symptoms at six months (4.2% vs 8.8%). Statistical analysis using Chi-Square test showed a positive response to Helicobacter pylori treatment during chronic urticaria. (x2-10.827; p<0.0001)

The successful eradication of Helicobacter pylori (H. pylori) is associated with  a substantial decrease in disease activity and exacerbation rates among patients suffering from chronic urticaria. These findings highlight the necessity of evaluating H. pylori infection when managing chronic urticaria and reinforce the rationale for implementing targeted screening and treatment strategies. This approach may lead to improved patient outcomes and a better understanding of the relationship between H. pylori and chronic urticaria.