D3.28 - Effectiveness of the Hypoallergenic Home Visit Program in Treating Moderate-to-Severe Allergic Rhinitis: An Environmental Control Study in Southern China

BackgroundEnvironmental factors play a crucial role in the development and progression of allergic diseases. With modern populations spending significantly more time indoors, controlling the home environment is particularly important. This study explores the effectiveness of environmental control in treating moderate-to-severe allergic rhinitis triggered by dust mite sensitization.

MethodThe study measured the levels and distribution of dust mite allergens in household dust from homes in Guangzhou, China, and surveyed household environments and patient habits to evaluate their impact on allergen levels. Dust mite allergens, including Dermatophagoides farinae (Der f 1) and Dermatophagoides pteronyssinus (Der p 1), were quantified using ELISA and semi-quantitative dust mite test kits for patient self-monitoring. Participants underwent allergen avoidance education, dust mite control guidance, and remote patient follow-up management. After two months, follow-up home visits were conducted to reassess household allergen levels and evaluate symptom improvements.

ResultsBetween August and December 2024, 128 dust samples were collected from 64 households. Dermatophagoides farinaeallergens were detected in 98% of bedding samples, with Der f 1 levels significantly higher than Der p 1. High concentrations of dust mite allergens (>10 μg/g) were observed in 88% of bedding samples. Predictors of high allergen levels included the presence of fabric furniture and mattresses older than one year. Dust mite allergens were most concentrated in mattresses, fabric sofas or cushions, and study chairs. Following the implementation of the Low-Allergen Home Visit Program, which included household allergen assessments, patient education, and remote follow-up management, significant reductions in household allergen levels were observed, accompanied by marked improvements in patient VAS scores.

ConclusionIn Guangzhou, Der f 1 is the predominant dust mite allergen in household dust, with exceptionally high concentrations in bedding and fabric furniture. The Hypoallergenic Home Visit Program effectively reduced household dust mite allergen levels and improved allergic rhinitis symptoms by combining household allergen assessments, patient education, and follow-up management.