D3.178 - Assessment of blood rheological properties in children with bronchial asthma

This study will assess the impact of moderate and severe asthma on red blood cell elasticity in children aged six to eighteen years. Particular attention will be paid to analyzing the reversible aggregation of these cells in patients receiving different drug treatment regimens.

A RheoScan laser aggregometer-strainmeter was used to analyze the aggregation and deformation characteristics of red blood cells. The study involved two groups of asthma patients: one group received standard treatment, and the other received standard treatment( inhaled glucocorticosteroids and long-acting bronchodilators) in combination with genetically engineered biological therapy 

The study showed that asthma patients receiving standard therapy alone had increased platelet aggregation (p<0.05). In contrast, patients treated with genetically engineered biological therapy demonstrated normal platelet aggregation rates. Furthermore, red blood cells in children receiving genetically engineered biological therapy were more deformable (Me 0,28 relative units) than those in the group receiving only standard treatment (Me 0,36 relative units) (p<0.05).

A RheoScan laser aggregometer-strainmeter was used to analyze the aggregation and deformation characteristics of red blood cells. The study involved two groups of asthma patients: one group received standard treatment, and the other received standard treatment in combination with genetically engineered biological therapy