D3.399 - Age-Dependent Manifestations of Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic esophagitis

Eosinophilic gastrointestinal disorders (EGIDs) are chronic immune-mediated conditions characterized by pathological eosinophilic infiltration. The clinical features and therapies for eosinophilic esophagitis (EoE) vary between children and adults. However, there is limited comparison of non-EoE EGIDs across different ages of disease onset.

We retrospectively analyzed data that included 94 patients (12 juveniles, 57 young adults, and 23 older adults) with a history of non-EoE EGIDs from a tertiary hospital.

Among the patients, 52.1% reported a history of allergic comorbidities. Diarrhea was more common in young adults (18–49 years) and nausea in juveniles (0–17 years) compared to older adults (aged ≥50 years). Vomiting was more frequent in juveniles (91.7%) followed by young adults (52.6%) and less common in older adults (24%) p < 0.001). Reduced bowel movement symptoms were less common in young adults compared to juveniles (p =0.034) and older adults (p = 0.025). Ascites were less frequent in older adults than in juveniles (p < 0.001) and young adults (p < 0.001). Juveniles had significantly higher peripheral white blood cell counts (p = 0.033) and eosinophil counts (5.52 vs. 1.23×109/L, p = 0.040) compared to older adults. Serum albumin levels in the juvenile group were significantly higher than in the young adult group (p =0.004) and older adult group (p =0.002), and total serum IgE levels were higher in the juvenile group than in the older adult group (467.5 vs. 118 g/L, p =0.002). Erythrocyte sedimentation rate (ESR) was higher in young and older adults than in juveniles (p =0.045, p =0.002， respectively). 

Clinical profiles of patients with non-EoE EGIDs vary by age of onset. A comprehensive understanding of the features in symptoms and therapies across different age groups can help accelerate diagnosis and enhance patient care.