100093 - Arcoxia - cause of erythema fixed drug

I present the case of a 58-year-old patient who complained of meteor sensitive pain in the dorso-lumbar spine. The rheumatologist established the diagnosis of lumbar discopathy and treatment with Mydocalm and Arcoxia was recommended. 3 days after administration, she presented erythematous plaques with a burning sensation with a diameter of 3 cm, well defined, at the level of the calf and bilaterally in the region of the ridges. After 2 days these plaques became bullous. This was followed by 0 weeks of corticosteroid therapy with antihistamines with remission of bullous lesions, but with the hyper pigmentary area. After a month he complained of lower back pain again and took Arcoxia again.  At the first administration, he presented erythematous plaque on the same areas as at the previous administration. We considered Arcoxia treatment to be the causative agent and no skin testing was performed because the patient had similar lesions upon readministration. Although COX2 inhibitors are especially effective drugs in patients with allergy on NSAIDs, they can induce erythema fixed drug in rare cases.