D2.441 - Association of High Sensitive-C-reactive Protein with Left Ventricle Remodeling in Type 1 Diabetes Mellitus

Type 1 Diabetes Mellitus (T1DM) induces an elevated cardiovascular risk, partly driven by chronic low-grade inflammation. High-sensitivity C-reactive protein (hs-CRP) is a marker of systemic inflammation, but the relationship with structural left ventricular (LV) remodeling in T1DM remains insufficiently studied.

This study included 80 T1DM patients (median age 35 years). Hs-CRP levels were measured using ELISA. Echocardiography was performed to assess LV remodeling parameters: LV mass index (LVMI), interventricular septum thickness (IVST), and LV posterior wall thickness (PWT). Pearson correlation and linear regression analyses were applied.

 Significant positive correlations were found between hs-CRP and LVMI (r=0.530, p=0.011), IVST (r=0.502, p=0.017), and PWT (r=0.450, p=0.035). A regression model indicated that each 1 mg/L increase in hs-CRP was associated with a 13.131 g/m² rise in LVMI.

Elevated hs-CRP is associated with more pronounced LV hypertrophy in T1DM patients. Hs-CRP may serve as a useful biomarker for identifying individuals at risk of diabetic cardiomyopathy. Incorporating hs-CRP assessment and echocardiography  could improve early detection and support the potential role of anti-inflammatory strategies in cardiovascular prevention in T1DM.