002001 - Comparative analysis of psoriasis and cancer frequency in patients and their families

Psoriasis and cancer are multifactorial, age-related diseases affecting European populations. Disease associations deepen our understanding of their genetic basis and play a crucial role in prognostic and preventive efforts. The aim of this study was to investigate the association between psoriasis and oncopathologies in Eastern Ukraine.

Clinical and genealogical data were analyzed for 313 psoriasis patients (184 women and 129 men) aged 20 to 91, alongside 639 patients with lung and gastrointestinal cancers (244 women and 395 men) aged 17 to 76, and 1,509 first- and second-degree relatives from the Kharkiv region, Eastern Ukraine. Among the psoriasis patients, individuals over 50 years old (79 women and 97 men) were selected for oncopathological assessment.

During the study period, the average age of oncopathology onset in population was 57.1 ± 1.5 years, 58.7 ± 1.5 for men and 55.0 ± 1.4 for women. For men, the average age at lung cancer onset was 55.5 ± 1.7 years, and 61.9 ± 1.4 years for gastrointestinal cancer. For women, these values were 50.5 ± 1.5 and 59.6 ± 1.3 years, respectively. The average age of psoriasis patients over 50 was 61.7 ± 2.0 years, 63.8 ± 2.4 for men and 59.6 ± 1.7 for women. No cases of cancer were observed among psoriasis patients over 50. However, the theoretically expected cancer frequency was 2.73% for men, 2.19% for women, and 2.47% overall. Among parents of psoriasis patients, the frequency of oncological pathologies was 0.27% and 0.51% in grandparents, in general 0.39%,  and were decreased compared to the expected 2.47% (p<0.05). The frequency of psoriasis among lung and gastrointestinal cancer patients was 0.50% for men and 0.82% for women, with an overall rate of 0.66%. Among the parents of these cancer patients, psoriasis frequency was 0.67% for women, 0.25% for men, and 0.43% overall, significantly lower than in the general population (p < 0.05).

Lower frequency of psoriasis was observed in families with gastrointestinal and lung cancer and vice versa, lower frequency of gastrointestinal and lung cancer was observed in families with psoriasis, as compared to general population rates. Further research is necessary to explore potential antagonistic mechanisms between psoriasis and oncopathologies.