D1.26 - Egg Allergy Persistence Beyond 8 Years of Age

To identify clinical and laboratory factors associated with egg allergy persistence in children diagnosed within the first two years of life and followed for over eight years.

We retrospectively analyzed 77 children with Immunoglobulin E (IgE)-mediated egg allergy (2013–2024). Patients were classified into persistent (n=12) and tolerance (n=65) groups based on outcomes after at least eight years of follow-up. Multivariate logistic regression was performed to identify independent factors

Persistence beyond age 8 occurred in 12 patients (15.6%). The multivariate analysis identified diagnosis at ≤5 months (OR 21.37), presence of multiple food allergies (OR 8.47), and higher baseline egg-white specific IgE (F1) levels (OR 1.09; indicating a 9% increase in the odds of persistence per 1 kU/L rise) as independent factors associated with persistence.

Early diagnosis, multiple food allergies, and high initial specific IgE levels are significantly associated with egg allergy persistence beyond age 8. Identifying these factors allows clinicians to stratify high-risk patients and customize management strategies