D2.269 - Predictors of Poor Disease Control in Greek Patients with Chronic Urticaria: Real-World Evidence from the CURE Registry

Chronic urticaria (CU) is a heterogeneous disease with substantial impact on patients’ quality of life. Real-world data describing disease characteristics and predictors of disease control in Southern European populations remain limited. This study aimed to describe the clinical profile of Greek patients with CU and identify factors associated with uncontrolled disease.

A cross-sectional analysis was performed using baseline data from Greek patients enrolled in the Chronic Urticaria Registry (CURE). Demographic characteristics, disease phenotype, comorbidities, and treatment patterns were evaluated. Disease activity, disease control, and quality of life were assessed using the Urticaria Activity Score (UAS7), the Urticaria Control Test (UCT), and the Dermatology Life Quality Index (DLQI), respectively. Continuous variables are presented as median (IQR) due to non-normal distribution. Multivariable logistic regression analysis was performed to identify predictors of uncontrolled disease, defined as UCT <12.

A total of 313 patients were included (mean age: 44.3 ± 16.9 years, female: 69%). angioedema 37.7%). At baseline, the predominant form of urticaria was chronic spontaneous urticaria (CSU) in 76.0% of patients and chronic inducible urticaria (CIndU) in 22.4%. Angioedema was present in 37.7% of patients.Among patients with CIndU ,the most frequent subtypes were cholinergic urticaria (30%), cold urticaria (27%), and symptomatic dermographism (27%), followed by delayed pressure urticaria (11%), while aquagenic and solar urticaria were rare. More than half of the patients (56.5%) had uncontrolled disease. Median Urticaria Control Test (UCT) was 5 (IQR 2–10) and median Urticaria Activity Score (UAS7) was 24 (IQR 14–35), indicating moderate-to-severe disease activity. Quality of life was also impaired, with a median Dermatology Life Quality Index (DLQI) of 13 (IQR 6–18).In multivariable analysis, the presence of angioedema was independently associated with uncontrolled disease (OR ≈ 2.9, p < 0.001), whereas age, sex, thyroid disease, and chronic inducible urticaria were not significant predictors

CU patients in Greece exhibit substantial disease burden and high rates of uncontrolled disease. The presence of angioedema emerged as the strongest predictor of poor disease control, highlighting the need for earlier recognition of high-risk patients and optimization of treatment strategies.