000869 - Severe Anaphylaxis in France nEtwork (SAFE): a new registry dedicated to severe anaphylaxis

Despite growing scientific interest in anaphylaxis, knowledge about severe anaphylaxis is currently insufficient, and many questions remain unanswered. Medical registries help improve our understanding and optimize the organization and quality of care towards personalized medicine. There are only few anaphylaxis registries across the world. 

In France, two ongoing registries collect data on anaphylaxis, the Allergy-Vigilance Network (since 2002) and the GERAP network (dedicated to perioperative hypersensitivity reactions, since 1989).

In 2026, the National Professional Council (CNP) of Allergology, in partnership with all stakeholders in allergology in France, particularly the French Society of Allergy (SFA), present the "Severe Anaphylaxis in France nEtwork" (SAFE) registry, the world's first medical registry dedicated to severe anaphylaxis. The originality of this new registry is to focus only on severe anaphylaxis and to bring together all stakeholders involved in the care of severe anaphylaxis (emergency care, anesthesia and intensive care, pediatrics, research institutions, and patient associations) (Figure 1). The SAFE registry will work in a synergic partnership with both ongoing French registries to collect and analyse data. We will collect data relating to the allergic reaction on an online case report form: patient’s history and details of the reaction entered into the online form by a healthcare professional for all patients, with additional data about the circumstances of the reaction and allergy workup provided by the patient or parent or legal guardian after informed consent.

The SAFE registry aims to help address knowledge gaps about severe anaphylaxis (epidemiology, risk factors, impact of cofactors, specificities according to age groups and triggers, most relevant therapeutic strategies, impact of recommendations) and contribute to a better understanding of severe anaphylaxis. It also represents a collaborative challenge by involving all stakeholders outside the field of allergology. It is up to all of us to meet this challenge for better patient care!