100480 - The Association Between Selective IgA Deficiency and Bronchial Asthma in Children Aged 4–18 Years: A Systematic Review
Background
INTRODUCTION
Selective IgA deficiency (sIgAD) is the most common immunodeficiency, typically presenting with an asymptomatic course. In symptomatic patients, bronchial asthma is the most prevalent allergic manifestation.
OBJECTIVE
To conduct a systematic literature review examining the association between sIgAD and bronchial asthma in children aged 4 to 18 years.
Method
A comprehensive search was conducted for randomized controlled trials, non-randomized controlled clinical trials, prospective and retrospective cohort studies, case-control studies, cross-sectional studies, reviews, and case reports published from 2000 onward in the Pubmed, Embase, Scopus, NICE, ICTRP, and Cochrane Databases. Studies included patients aged 4 to 18 years with sIgAD or bronchial asthma, selected based on predefined eligibility criteria.
Results
The prevalence of bronchial asthma in children with selective IgA deficiency ranged from 6.6% to 85%. Some studies confirmed an increased prevalence compared to the general population, while others refuted it. Patients with concurrent sIgAD and allergic disease exhibited a higher risk of severe manifestations, a more severe allergic phenotype, and complications affecting their prognosis and quality of life.
Conclusion
The association between asthma and sIgAD remains controversial, as a clear cause-effect relationship has yet to be established. Therefore, further studies on a larger patient population are required, along with immediate therapeutic intervention due to the increased risk of complications.
