000248 - Evaluation of the tolerability of the administration of subcutaneous immunotherapy in a cluster schedule, in patients with rhinoconjunctivitis and/or asthma with sensitization to Olea europaea with or without sensitization to grasses
Background
The cluster schedule for the administration of specific subcutaneous allergic immunotherapy (SCIT) allows the initiation period of immunotherapy to be reduced while maintaining efficacy and safety compared to conventional schedules. At present, there is no information available on the safety profile of cluster schedule in immunotherapy treatment whose composition includes Olea europaea. The aim of the study was to analyze the safety profile of the cluster SCIT regimen that includes Olea europaea in its composition, during the first year of treatment.
Method
A retrospective observational study was designed in patients with rhinoconjunctivitis and/or bronchial asthma, due to hypersensitivity to olive trees associated or not with grasses, who received SCIT in the last year with allergenic olive extract with or without grasses. Patients aged 5-65 years who had started the SCIT with a cluster schedule were included.
Results
Thirty-nine allergists included 245 patients, 51% (125) men, with a mean age of 26.6 years. Rhinoconjunctivitis and asthma symptoms were present in 59.2% (145), only rhinoconjunctivitis in 39.6% and 1.2% were only asthmatic. SCIT containing 50% olive tree and 50% grasses was administered to 69.8% (171) of the patients and 3,752 doses were administered.
A total of 166 adverse reactions were observed in 68 patients (27.8%) with no differences depending on the composition of immunotherapy (p=0.650). Local adverse reactions were76.5% (127) and 23.5% (39) systemic. Immunotherapy was discontinued due to an adverse reaction in 9 patients. A 4.42% adverse reaction rate per dose, 3.38% local per dose and 1.04% systemic per dose were observed in the first year of SCIT. Table 1 shows the proportion of adverse reactions observed by SCIT composition.
Conclusion
The safety profile of the cluster schedule of SCIT with composition containing Olea europaea with or without grasses was like that of the cluster and conventional schedules published with other allergen compositions.
