D1.106 - Grape polyphenols reduce the concentration of LPS in patients with asthma

Grape polyphenols can modulate the intestinal microbiome and decrease the translocation of hexacyl lipopolysaccharide of gram-negative flora (LPS) into the systemic bloodstream, decreasing the endotoxin load of the host.This effect is especially useful, as LPS occupies an important place in the pathogenesis of asthma.

This study included 70 patients with a verified diagnosis of asthma. The patients were divided into two groups. The intervention group (n=40), in addition to standard treatment, received a concentrate of grape polyphenols, according to the manufacturer's instructions in a dosage of 1 teaspoon per day during meals. The second group was a control group, and consisted of 30 patients who were comparable in gender and age to the experimental group. All patients had the content of LPS (Me (Q1-Q3); ng/mL) in plasma  determined by quantitative high-sensitivity enzyme-linked immunosorbent assay using ELISA test manufactured by Cloud Clone corp. (Wuhan, Hubei, China).

In patients of the interventional group using grape polyphenol concentrate, a significant decrease in the level of circulating LPS from 21.0 (14.9-31.2) to 14.7 (9.89-24.0) (p=0.008) was revealed. There were no significant changes in the level of LPS in the control group (p>0.05).

he use of polyphenolic grape concentrates in patients with asthma reduces the level of circulating blood endotoxin. This should have a positive effect on the course of the disease potentially reducing systemic low-grade inflammation.